En 2008 se llegó a la conclusión de que los cerebros con alzhéimer aúnan tanto una diabetes tipo 1, como una diabetes tipo 2. Y se rebautizó a esta desgarradora demencia como la flamante «diabetes tipo 3». En 2017, el glaucoma siguió una senda similar… y se propuso como la nueva diabetes tipo 4. Y quién sabe si en un futuro cercano también el párkinson será formalmente rebautizado como la esperanzadora diabetes tipo 5.
Aquí dejo el audio del capítulo y abajo las referencias.
Referencias (por orden de aparición):
De la Monte, S. M., & Wands, J. R. (2008). Alzheimer’s Disease Is Type 3 Diabetes–Evidence Reviewed. Journal of diabetes science and technology, 2(6), 1101-1113. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/
Daulatzai, M. A. (2017). Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer’s disease. Journal of Neuroscience Research, 95(4), 943-972. https://doi.org/10.1002/jnr.23777
Nigrovic, L. E., Kimia, A. A., Shah, S. S., & Neuman, M. I. (2012). Relationship between Cerebrospinal Fluid Glucose and Serum Glucose. New England Journal of Medicine, 366(6), 576-578. https://doi.org/10.1056/NEJMc1111080
Dineley, K. T., Jahrling, J. B., & Denner, L. (2014). Insulin Resistance in Alzheimer’s Disease. Neurobiology of disease, 72PA, 92-103. https://doi.org/10.1016/j.nbd.2014.09.001
Du, A. T., Schuff, N., Amend, D., Laakso, M. P., Hsu, Y., & Weiner, M. W. (2001). Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer’s disease. Journal of Neurology, Neurosurgery, and Psychiatry, 71(4), 441. https://doi.org/10.1136/jnnp.71.4.441
Sterling, N. W., Lewis, M. M., Du, G., & Huang, X. (2016). Structural Imaging and Parkinson’s Disease: Moving Toward Quantitative Markers of Disease Progression. Journal of Parkinson’s Disease, 6(3), 557-567. https://doi.org/10.3233/JPD-160824
Tan, J., Digicaylioglu, M., Wang, S. X. J., Dresselhuis, J., Dedhar, S., & Mills, J. (2019). Insulin attenuates apoptosis in neuronal cells by an integrin-linked kinase-dependent mechanism. Heliyon, 5(8), e02294. https://doi.org/10.1016/j.heliyon.2019.e02294
Watson, G. S., Peskind, E. R., Asthana, S., Purganan, K., Wait, C., Chapman, D., Schwartz, M. W., Plymate, S., & Craft, S. (2003). Insulin increases CSF Abeta42 levels in normal older adults. Neurology, 60(12), 1899-1903. https://doi.org/10.1212/01.wnl.0000065916.25128.25
Galizzi, G., & Di Carlo, M. (2022). Insulin and Its Key Role for Mitochondrial Function/Dysfunction and Quality Control: A Shared Link between Dysmetabolism and Neurodegeneration. Biology, 11(6), 943. https://doi.org/10.3390/biology11060943
Mullins, R. J., Diehl, T. C., Chia, C. W., & Kapogiannis, D. (2017). Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer’s Disease. Frontiers in Aging Neuroscience, 9, 118. https://doi.org/10.3389/fnagi.2017.00118
Ede, G. (2019). Parkinson’s, Alzheimer’s, and the New Science of Hope | Psychology Today. https://www.psychologytoday.com/gb/blog/diagnosis-diet/201906/parkinsons-alzheimers-and-the-new-science-hope
Hsieh, C.-F., Liu, C.-K., Lee, C.-T., Yu, L.-E., & Wang, J.-Y. (2019). Acute glucose fluctuation impacts microglial activity, leading to inflammatory activation or self-degradation. Nature, 9(1), 840. https://doi.org/10.1038/s41598-018-37215-0
Fournet, M., Bonté, F., & Desmoulière, A. (2018). Glycation Damage: A Possible Hub for Major Pathophysiological Disorders and Aging. Aging and Disease, 9(5), 880-900. https://doi.org/10.14336/AD.2017.1121
Kim, B., & Feldman, E. L. (2015). Insulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndrome. Experimental & Molecular Medicine, 47(3), e149. https://doi.org/10.1038/emm.2015.3
Sasaki-Hamada, S., Sanai, E., Kanemaru, M., Kamanaka, G., & Oka, J.-I. (2022). Long-term exposure to high glucose induces changes in the expression of AMPA receptor subunits and glutamate transmission in primary cultured cortical neurons. Biochemical and Biophysical Research Communications, 589, 48-54. https://doi.org/10.1016/j.bbrc.2021.11.108
Tomlinson, D. R., & Gardiner, N. J. (2008). Glucose neurotoxicity. Nature Reviews Neuroscience, 9(1), 36-45. https://doi.org/10.1038/nrn2294
Krashia, P., Nobili, A., & D’Amelio, M. (2019). Unifying Hypothesis of Dopamine Neuron Loss in Neurodegenerative Diseases: Focusing on Alzheimer’s Disease. Frontiers in Molecular Neuroscience, 12, 123. https://doi.org/10.3389/fnmol.2019.00123
Faiq, M. A., & Dada, T. (2017). Diabetes Type 4: A Paradigm Shift in the Understanding of Glaucoma, the Brain Specific Diabetes and the Candidature of Insulin as a Therapeutic Agent. Current Molecular Medicine, 17(1), 46-59. https://doi.org/10.2174/1566524017666170206153415
